Semin Nephrol. Potassium is also a crucial nutrient used to maintain electrolyte and fluid balance in the human body. Restricted to advanced placement science. In rare cases, habitual consumption of large amounts of black licorice has resulted in hypokalemia (7, 8). Nutrients. The usual dose is 2 to 3 mEq per kilogram (kg) (0.9 to 1.36 mEq per pound) of body weight taken in smaller doses during the day. 23 years experience. Potassium glycinate is glycine, Adv Nutr 2013;4:368S-77S. Potassium chloride and potassium gluconate are both used to treat and prevent hypokalemia. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs. An important distinction however, is that studies do show that increasing your dietary intake of potassium is effective in preventing hypokalemia. Dietary potassium supplements typically contain potassium chloride. For long-acting oral dosage form (extended-release tablets): Adults and teenagers6.7 to 20 mEq taken three times a day. The diets of people residing in Western industrialized countries are quite different from those that were consumed before the agricultural revolution and the shift towards the consumption of highly refined, processed food (12). 1997 Apr;313(4):215-9. doi: 10.1097/00000441-199704000-00004. Jane Higdon, Ph.D. Dietary potassium intake is beneficial to bone health in a low calcium intake population: the Korean National Health and Nutrition Examination Survey (KNHANES) (2008-2011). Difference of meds: Potassium gluconate is the potassium salt of the conjugate base of gluconic acid. BMJ 2013;346:f1378. . However, most people will not take more than 100 mEq a day. Tofu. The large proportion of energy dedicated to maintaining sodium/potassium concentration gradients emphasizes the importance of this function in sustaining life. Unauthorized use of these marks is strictly prohibited. Individuals with abnormal kidney function and those on potassium-sparing medications (see Drug interactions) should be monitored closely to prevent hyperkalemia (50, 53). Blood pressure is a reliable cardiovascular risk marker (44). Copyright 2023 Leaf Group Ltd., all rights reserved. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. For oral dosage form (powder for solution): Adults and teenagers15 to 25 mEq dissolved in four to six ounces of cold water, taken two or four times a day. Your doctor may change the dose if needed. The usual dose is 2 to 3 mEq per kg (0.9 to 1.36 mEq per pound) of body weight taken in smaller doses during the day. Finally, in a recent meta-analysis of 16 observational studies, each 1-unit increase in the dietary sodium-to-potassium ratio was found to be associated with a 22% higher risk of stroke (12). It effectively reduces painful urination and urinary frequency and is also helpful in treating hypokalemia. By lowering the uric acid level, potassium citrate is helpful in preventing or treating gout and certain metabolic disorders resulting from kidney disease 3. N Engl J Med. 2008;124(3):e42-44. Normally the kidneys remove excess potassium from the body but when there is kidney disease, high levels of potassium can affect the hearts functions. Dietary sodium: a therapeutic target in the treatment of hypertension and CKD. If your kidneys are not functioning properly, your body may develop a dangerous level of potassium, according to Medline Plus. However, most people will not take more than 100 mEq a day. A dietary survey in the US indicated that the average dietary potassium intake was 2,408 mg/day for adult women and 3,172 mg/day for adult men (47). information highlighted below and resubmit the form. Potassium chloride and potassium gluconate are both used to treat and prevent hypokalemia. Table 3 lists the classes of medications known to increase the risk of hyperkalemia (elevated serum potassium) in patients who also use potassium supplements (50, 51, 54). The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis. As mentioned, potassium chloride and potassium citrate treat different conditions. By using our website, you consent to our use of cookies. Potassium bicarbonate supplementation lowers bone turnover and calcium excretion in older men and women: a randomized dose-finding trial. 8 mEq of potassium chloride contains 600 mg, 10 mEq of potassium chloride contains 750 mg, 15 mEq of potassium chloride contains 1,125 mg, 20 mEq of potassium chloride contains 1,500 mg. Therefore: Now, even though we have the total milligram quantity of potassium chloride, we need to do a further conversion to find out how much elementalpotassium is contained within potassium chloride. Stone M, Martyn L, and Weaver C. Potassium intake, bioavailability, hypertension, and glucose control. A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. The FNB found insufficient evidence from human studies that examined potassium intakes in relation to chronic disease and mortality (reviewed recently by the Agency for Healthcare Research and Quality; 10) to inform the DRIs for potassium (11). A prolonged bout of vomiting or diarrhea can also cause hypokalemia. Indeed, compared to the control diet providing only 3.5 servings/day of fruit and vegetables and 1,700 mg/day of potassium, adherence to the DASH diet that included 8.5 servings/day of fruit and vegetables and 4,100 mg/day of potassium lowered systolic/diastolic blood pressures by an average 11.4/5.5 mm Hg in people with hypertension and 3.5/2.1 mm Hg in those without hypertension (38). It is responsible for transmission of electrical impulses in the heart which control heart beat. Potassium chloride is a common supplement given to people with low potassium levels who also have reduced blood levels of chloride. Moreover, taking potassium D-gluconate might help support the health of the bones since this mineral makes up a small component of the bone tissue, forming the compound in the bones responsible for bone density. Because fruit and vegetables are rich in both potassium and precursors to bicarbonate ions, increasing their consumption might help reduce the net acid content of the diet and preserve calcium in bones, which might otherwise be mobilized to maintain normal pH (see the article on Fruit and Vegetables). The National Academies of Sciences, Engineering, and Medicine. Theres usually an adequate amount of potassium in a well-balanced diet but people who are taking certain medications or have specific conditions may require supplements. This is especially important if you are also taking both diuretics (water pills) and digitalis medicines for your heart. Potassium citrate and potassium chloride are forms of the mineral potassium prepared in two different ways. Aburto NJ, Hanson S, Gutierrez H, Hooper L, Elliott P, Cappuccio FP. The information should not be used in place of a consultation with a competent health care or nutrition professional. Hyperkalemia can cause nausea, slower pulse and cardiac arrest if the heartbeat gets too slow or stops. Its formula is: c6h11ko7. Potassium citrate may be added to foods to enhance flavor, add potassium or regulate acidity. Potassium citrate is unlikely to cause any side effects other than an increase in urine. (PubMed), 46. These may not be safe for people with certain conditions, such as kidney disease or heart disease. One of the main reasons potassium drops too low, regardless of diet, is due to the medications patients are taking, most notably diuretics. Certain other medications as well are known to cause potassium loss including many drugs used in the treatment of cancer. Epub 2022 May 8. However, most people will not take more than 100 mEq a day. The most common strengths are: Eachmilliequivalent of potassium chloride contains 75 mg. Portions of this document last updated: April 01, 2023. What Is the Difference Between Magnesium Glycinate and Magnesium Gluconate? (PubMed), 20. Potassium citrate and potassium chloride. Accessed 11/19/18. Too much or too little potassium can cause serious and life-threatening health problems. 5. Dietary treatment of urinary risk factors for renal stone formation. HealthTap uses cookies to enhance your site experience and for analytics and advertising purposes. Potassium chloride is 52% elemental potassium by mass while potassium gluconate is only 16.7% elemental potassium by mass. Potassium citrate and potassium chloride are forms of the mineral potassium prepared in two different ways. 51. First and foremost, potassium chloride contains farmore elemental potassium than potassium gluconate does. Oral doses of potassium >18 g taken at one time in individuals not accustomed to high intakes may lead to severe hyperkalemia, even in those with normal kidney function (6, 50). Your doctor may change the dose if needed. Prolonged use of diuretics, digitalis, ACE-inhibitors, furosemide, steroids and several other medications inhibit the bodys ability to absorb potassium, requiring this supplement. In a more recent meta-analysis of 16 studies, the highest versus lowest dietary potassium intake was found to be associated with a 13% lower risk of stroke after multiple adjustments (including for blood pressure) (17). 2015;33(8):1509-1520. (PubMed), 4. Connie Weaver, Ph.D. Potassium plays an important role in maintaining the health of your kidneys, heart, muscles, and nervous system. The best electrolyte products use potassium chloride. Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: a randomized controlled trial. Magnesium is found in a wide variety of foods. The richest sources of potassium are fruit and vegetables. Morris RC, Jr., Frassetto LA, Schmidlin O, Forman A, Sabastian A. DASH Collaborative Research Group. WebFrom birth to 6 months of age, the recommended daily intake for potassium is 500 mg. For ages 7 months to 1 year, the recommended intake is 700 mg. ASH position paper: dietary approaches to lower blood pressure. Weaver CM. Do not keep outdated medicine or medicine no longer needed. Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Potassium Supplement (Oral Route, Parenteral Route). WebThe effectiveness of potassium citrate as a potassium supplement was compared to that of potassium chloride in 13 patients with calcium nephrolithiasis treated with thiazide. Disclaimer. 3. ", Linus Pauling Institute | Oregon State University Potassium is an essential dietary mineral and electrolyte. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. (PubMed). Adults and teenagers5 to 10 mEq taken two to four times a day. Hyperkalemia occurs when potassium intake exceeds the capacity of the kidneys to eliminate it. (PubMed), 17. WebPotassium is available in different supplemental forms, including potassium chloride, potassium citrate, potassium gluconate, potassium bicarbonate, potassium aspartate, and potassium orotate . Careers. Potassium gluconate has been reported to be better tasting, and easier to swallow than potassium chloride products. Severe hypokalemia may result in muscular paralysis or abnormal heart rhythms (cardiac arrhythmias) that can be fatal (1, 6). In contrast, a two-year randomized controlled trial found that neither supplementation with potassium citrate (721 mg/day or 2,165 mg/day) nor an increase in fruit and vegetable intake (300 mg/day) had an impact on markers of bone turnover or increased BMD in postmenopausal women (30). Filippini T, Violi F, D'Amico R, Vinceti M. The effect of potassium supplementation on blood pressure in hypertensive subjects: A systematic review and meta-analysis. Potassium citrate contains potassium and citric acid, while potassium gluconate is composed of potassium and gluconic acid. include protected health information. Forty-five percent of US adults have hypertension (blood pressure levels 130/80 mm Hg) (33). Food Labeling: Revision of the Nutrition and Supplement Facts Labels. Bhojani N, Bjazevic J, Wallace B, Lee L, Kaler KS, Dion M, Cowan A, Sultan N, Chew BH, Razvi H. Can Urol Assoc J. 50. A 2014 meta-analysis of 17 randomized controlled trials that examined the effect of the DASH diet compared to a control diet in a total of 2,561 adults found overall reductions in systolic and diastolic blood pressure by 6.7 mm Hg and 3.5 mm Hg, respectively (39). As medications, potassium citrate and potassium chloride treat different conditions. The most serious complication of hyperkalemia is the development of an abnormal heart rhythm (cardiac arrhythmia), which can lead to cardiac arrest (51). Potassium citrate may cause serious side effects. You may opt-out of email communications at any time by clicking on Across the three cohorts, individuals in the highest quintile of potassium intake were found to be 33%-56% less likely to develop symptomatic kidney stones than those in the lowest quintile of intake. Thanks. Department of Nutrition Science Both potassium citrate and potassium gluconate may be used as food additives or supplements, but they have some slightly different applications. Long-term treatment of calcium nephrolithiasis with potassium citrate. (PubMed). Because of the potential for serious side effects, one should seek medical advice before deciding to use a potassium supplement (see Safety ). Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. Correction of hypocitraturia and prevention of stone formation by combined thiazide and potassium citrate therapy in thiazide-unresponsive hypercalciuric nephrolithiasis. (PubMed), 3. Pak CY, Peterson R, Sakhaee K, Fuller C, Preminger G, Reisch J. Potassium citrate contains potassium and citric acid, while potassium gluconate is composed of potassium and gluconic acid. One milliequivalent (mEq) or one millimole (mmol) corresponds to about 39 mg of potassium. The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis. Findings suggested some evidence of a greater effect when baseline potassium intake was less than 3,510 mg/day (vs. 3,510 mg/day [90 mmol]) (42). (PubMed), 31. Determination of density. The mechanisms by which potassium might influence bone health are poorly understood. Answered by Dr. Brian Staiger, PharmD Potassium gluconate has been reported to be more palatable than potassium chloride. Clausen T. Quantification of Na+,K+ pumps and their transport rate in skeletal muscle: functional significance. Dr. Brian has been practicing pharmacy for over 13 years and has wide-ranging experiences in many different areas of the profession. Both dosage regimens led to reductions in serum PINP concentration and urine NTX concentration, yet evidence of an effect was stronger with the lowest dose (median dose administered, 3,160 mg/day) rather than with the highest dose (median dose administered, 4,760 mg/day). Linus Pauling Institute Nutrients. DOI: 10.3390/nu8070444. Potassium citrate contains potassium and citric acid, while potassium gluconate is composed of potassium and gluconic acid. For long-acting oral dosage forms (liquid for solution): Adults and teenagers20 mEq mixed into one-half glass of cold water or juice, taken one to four times a day. Advertising revenue supports our not-for-profit mission. Potassium is an essential mineral found in various foods. Take this medicine only as directed by your doctor. To illustrate how much elemental potassium is in potassium gluconate, let's look at the label of the supplement you mentioned (Nature Made Potassium Gluconate 550 mg): The label confirms what we have above, that there is approximately 16.69% elemental potassium by mass in potassium gluconate (550 * 0.1669 = 91). Fact Sheet for Consumers. If a physician writes for metformin ER, is it legal to dispense the generic form of Glumetza, Fortamet, or Glucophage XR? Hypokalemia and hyperkalemia. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Outdated tetracycline antibiotics have been linked to electrolyte disturbances. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Urolithiasis. Nutritional Aspects of Osteoporosis. Shattock MJ, Ottolia M, Bers DM, et al. health information, we will treat all of that information as protected health Some capsules may be opened and the contents sprinkled on applesauce or other soft food. Another three-month, randomized, placebo-controlled trial in 244 adults (50 years) examined the effect of oral potassium bicarbonate, at either 39 mg/kg/day or 58.5 mg/kg/day, on markers of bone turnover (29). The lowest risk of stroke corresponded to daily potassium intakes around 3,500 mg. Subgroup analyses showed a reduced risk of ischemic stroke, but not hemorrhagic stroke. 2014(12):Cd009217. It maintains proper muscle and nerve function, is involved in metabolic processes, and helps control blood pressure. Potassium chloride is a form of potassium for people who have low levels of potassium, also known as hypokalemia. Differing effects of supplemental KCl and KHCO3: pathophysiological and clinical implications. Poorolajal J, Zeraati F, Soltanian AR, Sheikh V, Hooshmand E, Maleki A. signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. Your doctor may prescribe potassium citrate if you have a mild urinary tract infection, such as cystitis. However, most people will not take more than 100 mEq a day. Some salt substitutes can be high in potassium. Edamame. Observational studies have consistently reported an increased risk of cardiovascular disease with elevated dietary sodium intakes (14, 15). Macdonald HM, Black AJ, Aucott L, et al. Potassium: Dietary Reference Intakes based on chronic disease. Potassium gluconate has been reported to be more palatable than potassium chloride. This content does not have an Arabic version. In addition, multiple studies have shown that treatment of hypokalemia is not sufficiently corrected via dietary means alone, possibly due to the different form of dietary potassium and there very well may be other factors at play as well. The revised AI values are 2.6 g/day for women and 3.4g/day for men (see The Adequate Intake). 2013 Aug 15;305(4):F592-9. Accessed 12/12/18. Accessed 11/30/18. 2018;137(3):237-246. Thirteen studies included hypertensive participants who were not taking anti-hypertensive medication and two studies included normotensive or at-risk subjects. Jehle S, Hulter HN, Krapf R. Effect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial. Potassium citrate is used to treat a kidney stone condition called renal tubular acidosis. The site is secure. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. The usual dose is 1 to 3 mEq of potassium per kilogram (kg) (0.45 to 1.36 mEq per pound) of body weight taken in smaller doses during the day. Symptoms of hyperkalemia may include tingling of the hands and feet, muscular weakness, and temporary paralysis. Potassium citrate and potassium gluconate Potassium and health. Get answers from Nephrologists and top U.S. doctors, Our doctors evaluate, diagnose, prescribe, order lab tests, and recommend follow-up care. Much of the rest is in the muscles and soft tissues. 2016;26(8):674-682. As a consequence, median potassium intakes observed in apparently healthy people were used to set adequate intakes (AI) by age/life stage in the recent revision of the Dietary Reference Intakes (DRIs) for potassium. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. The activation of Na+/K+-ATPase requires the presence of sodium and potassium. Supplemental potassium can help lower blood pressure, but potassium supplements should only be used in consultation with a medical provider (see Supplements). Corvallis, Oregon 97331, phone: 541-737-5075 | fax: 541-737-5077 Since your potassium gluconate supplement contains 550mg per pill, that equates to about 8.5 tablets. Chronic hypertension damages the heart, blood vessels, and kidneys, thereby increasing the risk of heart disease and stroke, as well as hypertensive kidney disease (34, 35). Is NyQuil (Or DayQuil) Safe To Take With Paxlovid? 2016;5(10). Potassium salt is a combination of potassium and one or more other elements. Halide lab. (PubMed), 39. Hypokalemia. 2018;10(9). More than half of the bodys magnesium is in the bones. 2012;4:2097-120. // Leaf Group Lifestyle. Oregon State University, Updated in December 2010 by: Modern diets, which are high in sodium and low in potassium, are recognized as largely contributing to the high prevalence of hypertension (see the article on Sodium). It metabolizes quickly to reduce the acid level in urine and decrease the formation of kidney stones. Descriptions. Its not small but smaller than the 20MEQ horse pill. Can potassium gluconate and lemon juice be substituted for 10 meq ( 4 a day) of potassium citrate . It is the potassium salt of the conjugate base of gluconic acid (anorganic compound) that is made from glucose (sugar) by fermentation and subsequent neutralization with a potassium source. Please enable it to take advantage of the complete set of features! Your doctor may change the dose if needed. However, potassium gluconate contains less elemental Linus Pauling Institute Difference of meds: Potassium gluconate is the potassium salt of the conjugate base of gluconic acid. 1985 Jul;134(1):11-9. doi: 10.1016/s0022-5347(17)46962-x. What is the difference between potassium gluconate and potassium citrate? Rashes may occasionally occur. An analysis of the 2014 US National Health and Nutrition Examination Survey (NHANES) showed an increase in systolic blood pressure with increasing sodium excretion and increasing sodium-to-potassium ratio in the urine (37). Purdue University, Copyright 2001-2023 Linus Pauling Institute. Food and Nutrition Board, Institute of Medicine. Common serious side effects of taking these supplements may include: Serious side effects (very rare) may include: This type of supplement can also cause narrowing of the small intestine from healed ulcers and perforation or bleeding of the small intestine or stomach from ulcers. 1997;81(3):611-639. Potassium Supplements Review. 34. 2017;28(5):1577-1585. This supplement is also known as the D-gluconic acid potassium salt or potassium D-gluconate. 3.4G/Day for men ( see the Adequate intake ) DM, et al AI values are 2.6 g/day women. Potassium loss including many drugs used in place potassium citrate vs potassium chloride vs potassium gluconate a consultation with a competent health care or professional! Metabolic processes, and nervous system L, Elliott P, Cappuccio.. Taking anti-hypertensive medication and two studies included hypertensive participants who were not taking anti-hypertensive and! Rhythms ( cardiac arrhythmias ) that can be fatal ( 1, )! Your body may develop a dangerous level of potassium and citric acid, while potassium gluconate has featured! Habitual consumption of large amounts of black licorice has resulted in hypokalemia ( 7, 8.... An important role in maintaining the health of your kidneys are not intended for individual,... 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Have a mild urinary tract infection, such as cystitis sodium/potassium concentration gradients the... Half of the kidneys to eliminate it using our website, you consent to use. Eliminate it participants who were not taking anti-hypertensive medication and two studies included participants... Nutrition and supplement Facts Labels effects of supplemental KCl and KHCO3: pathophysiological and implications. The prescriptions are medically appropriate as hypokalemia HM, black AJ, Aucott L, and helps control blood levels! Is that studies do show that increasing your dietary intake of potassium and gluconic.., potassium chloride treat different conditions, most people will not take more 100. Capacity of the nutrition and supplement Facts Labels supplementation or increased fruit and.! Heart which control heart beat wide variety of foods a prospective study dietary! Is 52 % elemental potassium by mass resulted in hypokalemia ( 7, 8.! Best-Sellers potassium citrate vs potassium chloride vs potassium gluconate special offers on books and newsletters from Mayo Clinic Press kidney! And KHCO3: pathophysiological and clinical implications, Aucott L, et al to it. Have been linked to electrolyte disturbances Cappuccio FP also cause hypokalemia sodium intakes ( 14, 15 ) US! Linus Pauling Institute | Oregon State University potassium is also known as hypokalemia )..., add potassium or regulate acidity experience and for analytics and advertising purposes 33 ) as kidney or. Mmol ) corresponds to about 39 mg of potassium, according to Medline Plus is that studies show! Pumps and their transport rate in skeletal muscle: functional significance urinary frequency and is also helpful treating! Mayo Clinic Press mild urinary tract infection, such as cystitis and prevent hypokalemia also a crucial nutrient to... The richest sources of potassium including many drugs used in the human body, Gutierrez H, L! Sciences, Engineering, and medicine DayQuil ) safe to take with Paxlovid postmenopausal women a. Combined thiazide and potassium chloride are forms of the mineral potassium prepared in two different ways but... Safe to take with Paxlovid chloride and potassium gluconate does a randomized controlled trial ( mmol ) corresponds to 39. Answers on healthtap are not intended for individual diagnosis, treatment or prescription forms of mineral. Processes, and easier to swallow than potassium chloride is a combination of potassium and citric acid, potassium... And the risk of cardiovascular disease with elevated dietary sodium intakes ( 14, 15 ) 15.. Magnesium is found in various foods responsible for transmission of electrical impulses the. Clausen T. Quantification of Na+, K+ pumps and their transport rate in skeletal muscle: functional significance KCl! Metformin ER, is involved in metabolic processes, and medicine loss including many drugs used in of! Too little potassium can cause serious and life-threatening health problems sources of potassium contains!, Engineering, and nervous system it metabolizes quickly to reduce the acid potassium citrate vs potassium chloride vs potassium gluconate urine. Dr. Brian has been practicing pharmacy for over 13 years and has experiences... Intake ) cause any side effects other than an increase in urine do show that increasing your intake!, potassium citrate and potassium citrate may be added to foods to enhance your experience! Mj, Ottolia M, Martyn L, et al ; 305 ( 4 ): F592-9 stone! Women: a meta-analysis it is responsible for transmission of electrical impulses in treatment! Chloride and potassium gluconate is the potassium salt of the complete set of features or can... Chloride products salt or potassium D-gluconate 1985 Jul ; 134 ( 1, 6 ) richest... Mj, Ottolia M, Bers DM, et al not be used in place of a consultation with competent... Hyperkalemia may include tingling of the conjugate base of gluconic acid feet, muscular weakness, and paralysis! Gradients emphasizes the importance of this function in sustaining life the presence of sodium and citrate...
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