We estimate the impact of different risk-reducing options at various ages on life expectancy.We apply our previously developed Monte Carlo simulation model of screening and prophylactic surgery in BRCA1/2 mutation carriers. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of Stage IV versus Stage I-III breast cancer; Cox proportional hazards regression was used to assess relative hazard (RH) of mortality.Five percent of invasive breast cancer was metastatic at diagnosis. Approximately 28% had a high school education or less, and 23% were non-English-speaking. Crown, A., Fazeli, S., Kurian, A. W., Ochoa, D. A., Joseph, K. A. Genome-Wide Analyses Characterize Shared Heritability Among Cancers and Identify Novel Cancer Susceptibility Regions. [3], Upon completing her fellowship, Kurian accepted a research scholar position supported by a Building Interdisciplinary Research Careers in Women's Health K12 award. Tao, L., Chu, L., Wang, L. I., Moy, L., Brammer, M., Song, C., Green, M., Kurian, A. W., Gomez, S. L., Clarke, C. A. There are no treatments specifically approved after recurrence or progression on a non Risk-reducing salpingo-oophorectomy has been shown to reduce ovarian cancer risk, but its association with breast cancer risk is less clear.To assess the association of RRSO with the risk of breast cancer in women with BRCA1 and BRCA2 pathogenic variants.This case series included families enrolled in the Breast Cancer Family Registry between 1996 and 2000 that carried an inherited pathogenic variant in BRCA1 (498 families) or BRCA2 (378 families). To estimate the risk of contralateral breast cancer (CBC) among women with germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2.The study population included 15,104 prospectively followed women within the CARRIERS study treated with ipsilateral surgery for invasive breast cancer. HER2 mutated cancer responds to treatment with neratinib. No patient had lymph node or distant metastases. View details for DOI 10.1158/1055-9965.EPI-14-1140. The odds ratio for higher impact of cancer worry was 0.81 (95% CI, 0.51 to 1.28) for multigene versus BRCA1/2-only testing. Charges, claims, and reimbursements are related to cost but are nontransparent and proprietary. However, these drugs are associated with side effects. Complete IHC data were available for 8,140 Asian women. In total, 2,187 deaths (1,122 from breast cancer) were observed through December 31, 2010. Thomas Kurian married a woman from Boston in typical style. Disparities in guideline-concordant care and pQoC persisted after controlling for medical discrimination, clinician mistrust, and decision-making.Interpersonal aspects of the patient-clinician interaction had an impact on pQoC but not receipt of guideline-concordant treatment and did not explain disparities in either outcome.Although breast cancer survivors' interpersonal interactions with clinicians did not influence receipt of appropriate treatment, intervention strategies to improve patient-clinician relations may help attenuate disparities in survivors' pQoC. We evaluated the performance of these models in a Chinese cohort, including males, before BRCA1/2 mutation testing.The five risk models were used to calculate the probability of BRCA mutations in probands with breast and ovarian cancers; 267 were non-BRCA mutation carriers (247 females and 20 males) and 43 were BRCA mutation carriers (38 females and 5 males).Mean BRCA prediction scores for all models were statistically better for carriers than noncarriers for females but not for males. We developed and evaluated the following two distinct NLP approaches to analyze free-text notes: a traditional rule-based model, using rules for metastatic detection from the literature and curated by domain experts; and a contemporary neural network model. Here, weestablish an invitro model for BRCA2-crisis that demonstrates chromatin remodeling and activation of an NF-B survival pathway in response to transient BRCA2 depletion. Individual genetic composition as fractions of three reference ancestries (African, East Asian, and European) was determined from ancestry-informative single-nucleotide polymorphisms. Zeidman, A., Benedict, C., Tolby, L., Zion, S., Fisher, S., Kurian, A. W., Berek, J. S., Woldeamanuel, Y., Schapira, L., Palesh, O. View details for DOI 10.1093/jamiaopen/ooz040, View details for PubMedCentralID PMC6994019, View details for DOI 10.2217/pme-2019-0045. Benedict, C., Fisher, S., Schapira, L., Chao, S., Sackeyfio, S., Sullivan, T., Pollom, E., Berek, J. S., Kurian, A. W., Palesh, O. Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element. Performance of mutation risk prediction models in a racially diverse multi-gene panel testing cohort. Patient-reported toxicities help to appraise the breast cancer treatment experience. These NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding criteria for high-penetrance genes associated with breast and ovarian cancer beyond BRCA1/2, pancreas screening and genes associated with pancreatic cancer, genetic testing for the purpose of systemic therapy decision-making, and testing for people with Ashkenazi Jewish ancestry. All patients underwent comprehensive BRCA1/2 genotyping, and homologous recombination deficiency was assessed by loss of heterozygosity (HRD-LOH) in pretreatment core breast biopsies.Among 80 patients, median age was 48 years; 19 patients (24%) had germline BRCA1 or BRCA2 mutations; clinical stage was I (13%), IIA (36%), IIB (36%), and IIIA (15%). Racial/Ethnic and Socioeconomic Differences in Short-Term Breast Cancer Survival Among Women in an Integrated Health System. He was an Arjay Miller Scholar. We identified de novo MBC patients from CCR and extracted information on distant recurrences from patient notes in EMR. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. Cronin, K., Petkov, V. I., Howlader, N., Howe, W., Schussler, N. C., Kurian, A. W., Penberthy, L. Relationship between rising bilateral mastectomy rates and increased use of neoadjuvant chemotherapy (NAC) in California, 1998-2012. National guidelines and peer-reviewed published literature were used to recommend that women with dense breast tissue at screening mammography follow supplemental screening guidelines based on breast cancer risk assessment. [1][2] Kurian earned her Bachelor of Arts degree in Human Biology at Stanford University before earning her medical degree from Harvard Medical School. Stanford is currently not accepting patients for this trial. To summarize evidence on the prevalence and spectrum of BRCA1 and BRCA2 BRCA1/2 mutations across racial and ethnic groups and discuss implications for clinical practice.The prevalence of BRCA1/2 mutations is comparable among breast cancer patients of African, Asian, white, and Hispanic descent: approximately 1-4% per gene. Compared to DCIS-only patients, patients with concurrent IBC had higher frequencies of CNAs in their DCIS samples. View details for DOI 10.1007/s10552-013-0260-7, View details for Web of Science ID 000324252500007, View details for DOI 10.1089/jayao.2013.0004, View details for Web of Science ID 000209404500003, View details for Web of Science ID 000335419600185, View details for Web of Science ID 000335419600392. Gallagher, S., Hughes, E., Wagner, S., Tshiaba, P., Rosenthal, E., Roa, B. Lin, G., Scheuner, M., Trosman, J., Sales, P., Ackerman, S., Douglas, M., Weldon, C., Kurian, A., Phillips, K. Multi-gene panel testing results prompt frequent and guideline adherent changes to cancer risk management recommendations based on clinician report. Methods: We conducted semi-structured interviews with 11 major US payers, covering >160 million lives. View details for DOI 10.1038/s41416-020-01185-w. For more information, please contact Karen Lau, 650-723-0658. Patients whose PLC was detected with LDCT-screening had a significantly lower 3-year incidence of BM (6.5%) versus those without (11.9%), with a cause-specific hazard ratio (HR) of 0.53 (p=0.001), adjusting for PLC stage, histology, diagnosis age and smoking status. The primary outcome was the number of relatives who ordered genetic testing.One hundred twenty-five of 277 patients completed surveys (45.2%). A Study Evaluating Safety and Efficacy of the Addition of ABT-888 Plus Carboplatin Versus the Addition of Carboplatin to Standard Chemotherapy Versus Standard Chemotherapy in Subjects With Early Stage Triple Negative Breast Cancer. Of 945 women who worried about finances, 679 (72.8%) indicated that physicians and their staff did not help. Yet, Asian Americans are more likely than other groups to have mastectomy or omit radiation after BCS.We applied polytomous logistic regression and recursive partitioning to analyze factors associated with mastectomy, or BCS without radiation, among 20,987 California Asian Americans diagnosed with stage 0 to II breast cancer from 1990 to 2007.The percentage receiving mastectomy ranged from 40% among U.S.-born Chinese to 58% among foreign-born Vietnamese. Most respondents were eligible for the trial offer (113 of 125; 90.4%). Factors associated with mastectomy included tumor characteristics such as larger tumor size, patient characteristics such as older age and foreign birthplace among some Asian Americans ethnicities, and additional factors including hospital [smaller hospital size, not National Cancer Institute cancer center, low socioeconomic status (SES) patient composition, and high hospital Asian Americans patient composition] and neighborhood characteristics (ethnic enclaves of low SES). This multicenter, randomized, double-blind study evaluated the efficacy, safety, and George Kurian lays out future vision of humankind built on social consciousness", "Why Google Cloud's new CEO Thomas Kurian quit Oracle after 22 years", "Oracle Fusion Middleware Wins Two InfoWorld Technology of the Year Awards", "Magic Quadrant for Application Infrastructure for Systematic Application Integration Projects", "Magic Quadrant for Application Infrastructure for Systematic SOA-Style Application Projects", "Magic Quadrant for Shared SOA Interoperability Infrastructure Projects", "Thomas Kurian: Executive Profile & Biography - Businessweek", "2007 JavaOne Conference -General Session Speakers", "Indian American Thomas Kurian is the new CEO of Google Cloud: Here's what you need to know about him", "For Oracle every revolution is an evolution", "Oracle's Software Development Reins in New Hands", "25 highest-paid men - Thomas Kurian (18)", "Oracle Execs, Apple's Tim Cook Among Highest-Paid in Tech", "Top Oracle Software Executive to Take Extended Leave", "Oracle says Kurian has resigned as president three weeks after he left to take time off", "Google Cloud CEO Diane Greene is out, to be replaced by former Oracle exec Thomas Kurian", "Thomas Kurian on his first year as Google Cloud CEO", https://en.wikipedia.org/w/index.php?title=Thomas_Kurian&oldid=1147957517, This page was last edited on 3 April 2023, at 07:04. 2,187 deaths ( 1,122 from breast cancer ) were observed through December 31,.. 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